archaeal-sgrna-designer

v0.1.2 suspicious
4.0
Medium Risk

sgRNA design for archaeal CRISPR-Cas9 editing (Methanosarcina and relatives)

🤖 AI Analysis

Final verdict: SUSPICIOUS

The package has low immediate operational risks, but concerns over metadata and repository activity level warrant further scrutiny.

  • Low repository activity
  • Incomplete author information
Per-check LLM notes
  • Network: No network calls detected, which is normal for a package focused on local computational tasks like sgRNA design.
  • Shell: No shell execution patterns detected, consistent with an application that does not require system-level operations.
  • Obfuscation: No obfuscation patterns detected, indicating low risk.
  • Credentials: No credential harvesting patterns detected, indicating low risk.
  • Metadata: The repository's low activity and incomplete author information suggest potential risks, but no clear indicators of malicious intent.

📦 Package Quality Overall: Low (4.6/10)

✦ High Test Suite 9.0

Test suite present — 1 test file(s) found

  • Test runner config found: pyproject.toml
  • 1 test file(s) detected (e.g. test_designer.py)
◈ Medium Documentation 5.0

Some documentation present

  • Detailed PyPI description (7260 chars)
○ Low Contributing Guide 2.0

No contributing guide or governance files found

  • No CONTRIBUTING, CODE_OF_CONDUCT, or governance files found
◈ Medium Type Annotations 5.0

Partial type annotation coverage

  • 13 type-annotated function signatures detected in source
○ Low Multiple Contributors 2.0

Single-author or unverifiable project

  • 1 unique contributor(s) across 14 commits in CameronCat/archaeal-sgrna-designer
  • Single author with few commits — possibly a personal or throwaway project

🔬 Heuristic Checks

✓ Outbound Network Calls

No suspicious network call patterns found

✓ Code Obfuscation

No obfuscation patterns detected

✓ Shell / Subprocess Execution

No shell execution patterns detected

✓ Credential Harvesting

No credential harvesting patterns detected

✓ Typosquatting

No typosquatting candidates detected

✓ Registered Email Domain

Email domain looks legitimate: yahoo.com>

✓ Suspicious Page Links

All external links appear legitimate

⚠ Git Repository History score 2.5

Git history flags: Repository has zero stars and zero forks

  • Repository has zero stars and zero forks
⚠ Maintainer History score 4.0

2 maintainer concern(s) found

  • Author name is missing or very short
  • Author "" appears to have only 1 package on PyPI (new or inactive account)
✓ Known CVE Vulnerabilities

No known vulnerabilities found in OSV database.

💡 AI App Starter Prompt

Use this prompt to build a project with archaeal-sgrna-designer 
Create a web-based application called 'ArchaealCas9Designer' that leverages the Python package 'archaeal-sgrna-designer' to assist researchers in designing single guide RNAs (sgRNAs) for CRISPR-Cas9 gene editing in archaea such as Methanosarcina and its relatives. This application should allow users to input their target DNA sequences and receive optimized sgRNA designs tailored for these specific organisms. Here are the key steps and features your app should include:

1. **User Interface**: Design a simple yet intuitive user interface where researchers can upload their DNA sequence files or directly paste the sequences into a text box.
2. **Sequence Validation**: Implement a feature that validates the uploaded sequences to ensure they meet the necessary criteria for sgRNA design (e.g., length, GC content).
3. **Design Optimization**: Utilize the 'archaeal-sgrna-designer' package to process the validated sequences and generate sgRNA designs optimized for the target archaeal species. Highlight any potential off-target effects and provide recommendations for minimizing them.
4. **Results Presentation**: Display the designed sgRNAs in a clear format, including the sequence, location within the genome, and any relevant scores or metrics provided by the 'archaeal-sgrna-designer' package.
5. **Export Options**: Allow users to export their results in various formats (e.g., CSV, Excel) for further analysis or record-keeping.
6. **Documentation and Support**: Include comprehensive documentation explaining how to use the application effectively, along with FAQs and contact information for technical support.

This application will significantly streamline the process of designing sgRNAs for archaeal CRISPR-Cas9 experiments, making it accessible to a wider range of researchers.

💬 Discussion Feed

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